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Inhibitory effects of phylligenin and quebrachitol isolated from Mitrephora vulpina on platelet activating factor receptor binding and platelet agregation.


Citation

Moharam, Bushra Abdulkarim and Jantan, Ibrahim and Jalil, Juriati and Shaari, Khozirah (2010) Inhibitory effects of phylligenin and quebrachitol isolated from Mitrephora vulpina on platelet activating factor receptor binding and platelet agregation. Molecules, 15 (11). pp. 7840-7848. ISSN 1420-3049

Abstract

Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch. They were evaluated for their ability to inhibit platelet activating factor (PAF) receptor binding to rabbit platelets using 3H-PAF as a ligand and their antiplatelet aggregation effect in human whole blood induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP). Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC50 values of 13.1 and 42.2 µM, respectively. The IC50 value of phylligenin was comparable to that of cedrol (10.2 µM), a potent PAF antagonist. Phylligenin also showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.3390/molecules15117840
Publisher: MDPI
Keywords: Mitrephora vulpina; Phylligenin; Quebrachitol; Platelet activating factor (PAF) antagonist; Antiplatelet activity.
Depositing User: Najwani Amir Sariffudin
Date Deposited: 28 Oct 2013 03:55
Last Modified: 21 Oct 2015 03:53
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules15117840
URI: http://psasir.upm.edu.my/id/eprint/15237
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