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In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.


Citation

Khalid, Syamimi and Shaik Mossadeq, Wan Mastura and Daud , Ahmad Israf and Hashim, Puziah and Rejab, S. and Shaberi, A.M. and Mohamad, Azam Shah and Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan (2010) In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Medical Principles and Practice, 19 (4). pp. 255-259. ISSN 1011-7571; ESSN:1423-0151

Abstract

To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1159/000312710
Publisher: Karger: Open Access Journals
Keywords: Analgesic; Opioid system; Tamarindus indica.
Depositing User: kmportal
Date Deposited: 20 Nov 2013 05:11
Last Modified: 22 Sep 2015 07:41
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000312710
URI: http://psasir.upm.edu.my/id/eprint/15172
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