Citation
Shaari, Khozirah and Kee, Cheng Ling and Mat Rashid, Zalilawati and Tan, Pei Jean and Abas, Faridah and Mohd Raof, Salahudin and Zainal, Zurina and Lajis, Nordin and Mohamad, Habsah and Ali, Abdul Manaf
(2009)
Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
Marine Drugs, 7 (1).
pp. 1-8.
ISSN 1660-3397
Abstract
In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Food Science and Technology |
| DOI Number: | https://doi.org/10.3390/md7010001 |
| Publisher: | MDPI |
| Keywords: | Marine sponge; Aaptos aaptos; Aaptaminoids; Alkaloids; Cytotoxicity. |
| Depositing User: | Khairil Ridzuan Khahirullah |
| Date Deposited: | 06 Nov 2013 03:37 |
| Last Modified: | 06 Nov 2013 03:37 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/md7010001 |
| URI: | http://psasir.upm.edu.my/id/eprint/13851 |
| Statistic Details: | View Download Statistic |
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