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Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models


Citation

Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan and Morsid, Nur Atiqah and Aris, Anwariah and Zainal, Hairani and Mohd Pojan, Nur Hidayu and Kumar, Gopalan Hanan (2009) Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models. Methods and Findings in Experimental and Clinical Pharmacology, 31 (2). pp. 81-88. ISSN 0379-0355; ESSN: 2013-0155

Abstract

The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1358/mf.2009.31.2.1353876
Publisher: Prous Science
Keywords: Anti-inflammatory; Antinociceptive; Antipyretic; Aqueous extract; Solanum nigrum
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 15 Dec 2014 08:08
Last Modified: 01 Sep 2016 03:18
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1358/mf.2009.31.2.1353876
URI: http://psasir.upm.edu.my/id/eprint/13173
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