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Antitumour Promoting Activity And Mode Of Action Of Methanolic Extracts Of Selected Malaysian Seaweeds And Oil Palm Fronds

Namvar, Farideh (2009) Antitumour Promoting Activity And Mode Of Action Of Methanolic Extracts Of Selected Malaysian Seaweeds And Oil Palm Fronds. PhD thesis, Universiti Putra Malaysia.

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Abstract

Dietary and non dietary biophenols may potentially be chemoprotective against various cancers. This research aims to investigate the cancer preventive and tumoricidal properties of selected Malaysian seaweeds and oil palm leaves as a source of phenolic compounds. Initially, the anti-proliferation activities of, red (Eucheuma cottonii), green (Caulerpa lentillifera) and brown (Sargassum polycystum) seaweeds methanolic extract, against five important human cancer cell lines MCF-7, (human breast carcinoma cell line, estrogen positive) MDA-MB-231, (human breast carcinoma cell line, estrogen negative) HeLa, (human cervical adenocarcinoma cell line) HepG2, (human hepatocellular carcinoma cell line) HT-29, (human colon carcinoma) and normal Vero (African green monkey kidney cell line) were assessed. The MTT assays indicated that the 3 seaweeds extracts were cytotoxic against all these cancer cell lines in a dose-dependent manner,with Eucheuma cottonii having the greatest inhibition activity.

Item Type:Thesis (PhD)
Subject:Algae - Malaysia
Subject:Oil palm - Malaysia
Subject:Cancer - Prevention
Chairman Supervisor:Professor Suhaila Mohamed, PhD
Call Number:IB 2009 18
Faculty or Institute:Institute of Bioscience
ID Code:12061
Deposited By: Mohd Nezeri Mohamad
Deposited On:18 Jul 2011 06:58
Last Modified:27 May 2013 07:50

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