Protective Effect Of Phenorbarbitone And Griseofulvin Againt Signal Grass (Brachiaria Decumbens)Toxiciti In Sheep
Ab. Hamid, Hasiah (2001) Protective Effect Of Phenorbarbitone And Griseofulvin Againt Signal Grass (Brachiaria Decumbens)Toxiciti In Sheep. Masters thesis, Universiti Putra Malaysia.
The protective effect of phenobarbitone and griseofulvin against signal grass (B. decumbens) toxicity were studied in fifty-three Wiltshire x Malin (Indigenous Malaysian) male sheep. Twenty-six animals were used in phenobarbitone experiment and twenty-seven animals were used in griseofulvin experiment. Grazing on signal grass significantly decreased the concentration of cytochrome P-4S0 and the activity of drug metabolizing enzyme, viz. aminopyrine-N-demethylase, aniline-4- hydroxylase, UDP-glucuronyltransferase and glutathione-S-transferase in liver and kidney of sheep. The concentration of cytochrome P-4S0 was determined in microsomal fraction according to the method of Omura and Sato (1964a) as described by Mazel (1971). The activities of aminopyrine-N-demethylase and aniline-4- hydroxylase were determined using Mazel, 1971 method by estimating the
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